Publications by authors named "G Pula"
Article Synopsis
- Anorexia nervosa (AN) is the psychiatric disorder with the highest risk of mortality, and adult patients often drop out of treatment due to denial of their condition.
- A new assessment protocol was developed to understand the psychological factors that influence treatment success or dropout in patients undergoing a psychodynamic approach for eating disorders.
- The case study of a 45-year-old woman with long-standing AN illustrates how psychological issues like denial can impact treatment compliance and hinder the establishment of a therapeutic relationship.
The ability of synthetic peptides inhibitors of NOX1 to effectively block the production of ROS by the enzyme was studied with different methodologies. Specifically, taking advantage of our understanding of the active epitope of the regulatory NOX1 subunit NOXA1 as a potent inhibitor of NOX1-derived O⋅ formation, a panel of peptidomimetic derivatives of this peptide were designed and synthesized with the aim of improving their activity and increasing their stability in plasma. The results highlighted that improved efficacy and potency was found for both the peptide-peptoid hybrid GS2, whereas stapled peptide AC5 and its precursor showed higher stability despite lower biological potency.
View Article and Find Full Text PDFReactive oxygen species (ROS) are highly unstable oxygen-containing molecules. Their chemical instability makes them extremely reactive and gives them the ability to react with important biological molecules such as proteins, nucleic acids, and lipids. Superoxide anions are important ROS generated by the reduction of molecular oxygen reduction (i.
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