[Medicines withdrawn in other countries due to safety concerns: should they continue to be available in the Argentine pharmaceutical market?].

Introduction: Numerous medicines have been withdrawn from the market because of the risks of serious adverse effects. The objective of this study was to identify in the Argentine pharmaceutical market (APM) the presence of medicines withdrawn in other countries due to safety problems, to analyze the information on their risks and to propose recommendations.

Method: observational, descriptive study that explored the presence in the APM, until May 2021, of 462 medicines withdrawn in other countries.

[Cardiovascular risk of non-steroidal anti-inflammatory drugs].

Non-steroidal anti-inflammatories (NSAIDs) are among the most commonly used drugs in clinical practice. They block cyclooxygenases (COX) enzymes, but the degree of inhibition of COX-1 and COX-2 varies between them. In general, NSAIDs are classified in selective COX-2 or coxibs and non-selective or traditional NSAIDs.

Effect of physical activity on the pharmacokinetics of ceftazidime in mice.

Background: The aim of the present work was to assess comparatively the pharmacokinetic profile of ceftazidime (CAZ) in trained and non-trained mice.

Methods: The study was performed on 256 mice divided at random into four groups: long-term physically trained mice with (E1a) and without (E1b) physical activity prior to the administration of CAZ, and untrained mice with (E2a) and without (E2b) physical activity prior to the administration of the antibiotic. CAZ was administered intramuscularly (25 mg/kg) to all mice, and blood samples were obtained at different time points.