Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human Lectins.

Carbohydrate-binding proteins (lectins) play vital roles in cell recognition and signaling, including pathogen binding and innate immunity. Thus, targeting lectins, especially those on the surface of immune cells, could advance immunology and drug discovery. Lectins are typically oligomeric; therefore, many of the most potent ligands are multivalent.

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation.

Background: Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction between primary and secondary Paget disease is crucial to management.

Case Presentation: We report an unusual case of vulvar Paget disease associated with massive dermal vascular embolization, cervicovaginal involvement and metastasis to inguinal and retroperitoneal lymph nodes.

Renal involvement in paroxysmal nocturnal haemoglobinuria: a brief review of the literature.

Introduction: Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired genetic disorder characterized by complement-mediated haemolysis, thrombosis and variable cytopenias. Renal involvement may occur and causes significant morbidity to these patients.

Objective: To review the literature about pathophysiology and provide recommendations on diagnosis and management of renal involvement in PNH.

[The outset of heart transplantation in Belgium or the conjunction of resolute patients, trustful cardiologists and surgeon ready to go ahead].

The first heart transplantation (HTx) in Belgium was performed by us at university hospital Brugmann on August 23, 1973. At this time, organ procurement was still a sensitive procedure not regulated as well as it is nowadays. Among other difficulties, diagnosis of rejection after the operation was only based upon clinical signs and electrocardiographic voltage variations.

Right-to-left shunting with normal pulmonary pressure complicating atrial septal defect surgery.

We report on a patient in whom a right-to-left shunt with normal pulmonary arterial pressures occurred after surgery of an inferior vena caval sinus venosus-type atrial septal defect. In addition to the inferior vena cava to left atrium anatomic defect, the exceptional occurrence of a post-operative right atrial inflow stenosis contributed to the right-to-left shunting.