Tissue-Specific DNA Methylation Changes in CD8 T Cells During Chronic Simian Immunodeficiency Virus Infection of Infant Rhesus Macaques.

Robust CD8 T cell responses are critical for the control of HIV infection in both adults and children. Our understanding of the mechanisms driving these responses is based largely on studies of cells circulating in peripheral blood in adults, but the regulation of CD8 T cell responses in tissue sites is poorly understood, particularly in pediatric infections. DNA methylation is an epigenetic modification that regulates gene transcription.

Investigating the effect of rTMS over the temporoparietal cortex on the Right Ear Advantage for perceived and imagined voices.

A Right Ear Advantage (REA) is well-established in perceptual tasks but it has been found also during imagery. It is ascribed to the left temporoparietal activity for language, and it can be absent/reversed in some clinical conditions including auditory hallucinations. We applied 1-Hz repetitive TMS over TP3/TP4 (left/right language areas) identified through neuronavigation in 18 healthy participants, before administering a modified white noise (WN) speech illusion paradigm: a voice was presented at one ear, at the same or lower intensities with respect to binaural WN.

Artistic turns: laterality in paintings of kisses and embraces.

Many lateral biases exist in human behavior, often implicit and not deliberated. Romantic kissing and embracing received experimental attention in the last three decades. We investigated laterality in paintings depicting these social interactions using two methodologies to assess whether painters depicted such biases and whether these biases could be due to observers' aesthetic preferences or painters' ability in portraying naturalistic interactions.

The effect of aging on the dual-route model of emotion processing applied to memory recognition.

Objective: Emotional faces are automatically processed in the human brain through a cortical route (conscious processing based on high spatial frequencies, HSF) and a subcortical route (subliminal processing based on low spatial frequencies, LSF). How each route contributes to emotional face recognition is still debated, and little is known about this process in aging.

Method: Here, 147 younger adults (YA) and 137 older adults (OA) were passively presented with neutral, happy, and angry faces, shown as (a) unfiltered, (b) filtered at LSF, and (c) hybrid (emotional LSF superimposed to the neutral HSF of the same face).