Publications by authors named "G Prestat"
An atom-economical intermolecular iron-catalyzed oxyamination of alkenes is described herein. The insertion of oxygenated and nitrogenated moieties from the hydroxylamine substrate was observed with full regio- and chemo-selectivity for terminal alkenes in good yields. HFIP as a solvent appeared to have a synergistic effect with the iron catalyst to promote the formation of the oxyaminated products.
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- Mutations in the CFTR gene cause Cystic Fibrosis, with the most common being the F508del mutation, which disrupts airway fluid transport and leads to severe respiratory issues.
- The study focused on a compound called c407, which has been shown to correct CFTR dysfunction in cells with the F508del mutation.
- Results indicated that c407 improved chloride conductance in a mouse model of CF and was well tolerated, suggesting its potential as a safe treatment for Cystic Fibrosis.
C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein.
View Article and Find Full Text PDFCystic fibrosis (CF) is the most frequent life-limiting autosomal recessive disorder in the Caucasian population. It is due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Current symptomatic CF therapies, which treat the downstream consequences of CFTR mutations, have increased survival.
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