Publications by authors named "G Poulin"
Article Synopsis
- - The 2024 update of the 2018 National Guideline for Clinical Management of Opioid Use Disorder emphasizes the need for current scientific evidence to inform treatment practices for opioid use disorder in Canada.
- - A comprehensive review from 2017 to 2023 was conducted to revise the guidelines, involving a national committee including those with personal experience in opioid use disorder, and ensuring quality through established methods.
- - Key changes in the recommendations include recognizing methadone and buprenorphine as equally effective first-line treatments, introducing slow-release oral morphine as a second-line option, and highlighting that psychosocial interventions should be optional rather than mandatory.
Article Synopsis
- Fast axonal transport, essential for proper neuron function, involves kinesins and cytoplasmic dynein, with this study focusing on kinesin-1's role in transporting dense core vesicles (DCVs) in *C. elegans*.
- Mutants lacking kinesin light chains (klc-1 and klc-2) and the motor subunit (unc-116) showed impaired DCV transport, with differences in transport speed and effects on locomotion and drug responses.
- Additionally, while unc-116 mutants had a shorter lifespan, klc-1 and klc-2 mutants extended the lifespan of a specific transgenic strain, highlighting their distinct roles in influencing both vesicle transport and overall organism health
Background: In Canada, low awareness of evidence-based interventions for the clinical management of alcohol use disorder exists among health care providers and people who could benefit from care. To address this gap, the Canadian Research Initiative in Substance Misuse convened a national committee to develop a guideline for the clinical management of high-risk drinking and alcohol use disorder.
Methods: Development of this guideline followed the ADAPTE process, building upon the 2019 British Columbia provincial guideline for alcohol use disorder.
Genetic perturbation in different genetic backgrounds can cause a range of phenotypes within a species. These phenotypic differences can be the result of the interaction between the genetic background and the perturbation. Previously, we reported that perturbation of gld-1, an important player in the developmental control of Caenorhabditis elegans, released cryptic genetic variation (CGV) affecting fitness in different genetic backgrounds.
View Article and Find Full Text PDF