Publications by authors named "G Porebski"
Article Synopsis
- Initiation of the bradykinin cascade can cause angioedema attacks without wheals, particularly in hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH), highlighting a complex interplay between mast cells and this process.
- * Recent findings suggest mast cell degranulation might activate the kallikrein-kinin system, leading to bradykinin formation, while also revealing a connection between bradykinin and histamine symptoms, despite their distinct clinical presentations.
- * Exploring mast cell-related receptors, specifically MRGPRX2, and their ligands could help understand individual variability in HAE-C1-INH responses, raising important questions about potential therapeutic interventions targeting mast cell activation versus br
Article Synopsis
- Angioedema (AE) is a condition characterized by localized swelling in the skin or mucous membranes and can be hereditary or acquired, making its classification complex due to various underlying mechanisms and taxonomies.
- The DANCE initiative, involving 91 experts from 35 countries, aimed to create a unified consensus on the definition, acronyms, and classification of AE through an extensive online discussion and voting process over 16 months.
- The resulting DANCE classification introduces five types of AE, standardizes terminology, and is designed to enhance research and patient care while complementing existing clinical guidelines without replacing them.
A Core Outcome Set for Efficacy of Acute Treatment of Hereditary Angioedema.
J Allergy Clin Immunol Pract
June 2024
Background: Clinical trials investigating drugs for the acute treatment of hereditary angioedema attacks have assessed many different outcomes. This heterogeneity limits the comparability of trial results and may lead to selective outcome reporting bias and a high burden on trial participants.
Objective: To achieve consensus on a core outcome set composed of key outcomes that ideally should be used in all clinical efficacy trials involving the acute treatment of hereditary angioedema attacks.
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis.
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