Publications by authors named "G Polton"

Mucosal melanoma is a rare melanoma subtype associated with a poor prognosis and limited existing therapeutic interventions, in part due to a lack of actionable targets and translational animal models for preclinical trials. Comprehensive data on this tumour type are scarce, and existing data often overlooks the importance of the anatomical site of origin. We evaluated human and canine oronasal mucosal melanoma (OMM) to determine whether the common canine disease could inform the rare human equivalent.

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Article Synopsis
  • * After surgery, including amputation and removal of affected vertebrae, the diagnosis was confirmed as extraskeletal osteosarcoma through histopathology.
  • * Remarkably, one year post-surgery, the dog was back to normal exercise and showed no signs of cancer returning, marking this as the first known case of this specific type of tumor in dogs.
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Melanoma of the dog and cat poses a clinical challenge to veterinary practitioners across the globe. As knowledge evolves, so too do clinical practices. However, there remain uncertainties and controversies.

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A toroidal high-intensity focused ultrasound (HIFU) transducer was used to expose normal bladder wall tissues non-invasively in vivo in a porcine model in order to investigate the potential to treat bladder tumors. The transducer was divided into 32 concentric rings with equal surface areas, operating at 2.5 MHz.

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