Publications by authors named "G Plewig"
Article Synopsis
- * The term SAPHO syndrome was introduced in 1987 to describe a group of inflammatory diseases, including synovitis and pustulosis, but some experts suggest reclassifying it as Sasaki syndrome to better represent specific conditions like PPP without skin issues.
- * Understanding the pathophysiology of these disorders remains incomplete; expert opinion now favors a more detailed approach using high-throughput sequencing to help dissect
Pioneers in Dermatology and Venereology: an interview with Prof. Gerd Plewig.
J Eur Acad Dermatol Venereol
January 2021
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland-bearing skin in the axilla, groin and under the breasts. Mutations of the gamma secretase gene complex, which is essential in the activation of Notch signalling pathways, were shown in some families with HS and in a few sporadic cases. Although an imbalance in Notch signalling is implicated in the pathogenesis, the exact mechanism of HS development is yet unknown.
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