Publications by authors named "G Plant"

In recent years, the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine. Considering the non-regenerative nature of the mature central nervous system, the concept that "blank" cells could be reprogrammed and functionally integrated into host neural networks remained intriguing. Previous work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells, such as neurons.

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Following a unilateral post-chiasmal lesion of the geniculo-striate pathway, patients develop homonymous visual field defects. Using classical perimetry, patients with 'complete' homonymous hemianopia are unaware of stimuli in the affected hemifield. However, some show preserved vision in the affected hemifield in which the conscious perception of moving stimuli is preserved (Riddoch phenomenon).

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Article Synopsis
  • The ellipsoid zone (EZ) on macular optical coherence tomography (OCT) scans shows high intensity due to dense mitochondria, potentially indicating mitochondrial function and offering insights into eye diseases.
  • A new analysis tool was developed to measure EZ reflectivity in patients with optic neuritis and other optic neuropathies compared to healthy individuals, revealing reliable ratios that indicate differences in reflectivity.
  • Results suggest that EZ reflectivity is lower in certain neuroinflammatory and mitochondrial disorders, indicating its potential as a non-invasive biomarker for mitochondrial health, but further research is needed.
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Glaucoma is a progressive optic neuropathy resulting from pathological changes at the optic disc due to elevated intraocular pressure. Its diagnosis, treatment and follow-up are almost entirely conducted in ophthalmology clinics, with screening conducted by community optometrists. Despite this, neurologists may encounter glaucoma in both its acute presentation (as angle closure, presenting as acute headache) and its chronic forms (often as optic neuropathy of unknown cause).

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