Maximally mutable Laurent polynomials.

We introduce a class of Laurent polynomials, called maximally mutable Laurent polynomials (MMLPs), which we believe correspond under mirror symmetry to Fano varieties. A subclass of these, called rigid, are expected to correspond to Fano varieties with terminal locally toric singularities. We prove that there are exactly 10 mutation classes of rigid MMLPs in two variables; under mirror symmetry these correspond one-to-one with the 10 deformation classes of smooth del Pezzo surfaces.

Embryonic and neonatal myosin heavy chain in denervated and paralyzed rat skeletal muscle.

Using immunofluorescence procedures with specific polyclonal and monoclonal antimyosin antibodies we have found that embryonic and neonatal myosin heavy chains (MHCs), which in rat skeletal muscle disappear during the first weeks after birth, are reexpressed in adult muscle after denervation. Reactivity for embryonic and neonatal MHCs was detected in some fibers as early as 3 days after denervation, became more evident by 7 days, and occurred exclusively in the type 2A fiber population. Paralysis of innervated muscles by tetrodotoxin block of the sciatic nerve also resulted in the reappearance of embryonic and neonatal MHCs in type 2A fibers.

Effect of Ca2+, peroxides, SH reagents, phosphate and aging on the permeability of mitochondrial membranes.

The mechanism by which a number of agents such as hydroperoxides, inorganic phosphate, azodicarboxylic acid bis(dimethylamide) (diamide), 2-methyl-1,4-naphthoquinone (menadione) and aging, induce Ca2+ release from rat liver mitochondria has been analyzed by following Ca2+ fluxes in parallel with K+ fluxes, matrix swelling and triphenylmethylphosphonium fluxes (as an index of transmembrane potential). Addition of hydroperoxides causes a cycle of Ca2+ efflux and reuptake and an almost parallel cycle of delta psi depression. The hydroperoxide-induced delta psi depression is biphasic.