Safety of Rotavirus Vaccination in Preterm Infants Admitted in Neonatal Intensive Care Units in Sicily, Italy: A Multicenter Observational Study.

Rotavirus (RV) is among the most common vaccine-preventable diseases in children under five years of age. Despite the severity of rotavirus pathology in early childhood, rotavirus vaccination for children admitted to the neonatal intensive care unit (NICU), who are often born preterm and with various previous illnesses, is not performed. This multicenter, 3-year project aims to evaluate the safety of RV vaccine administration within the six main neonatal intensive care units of the Sicilian Region to preterm infants.

Clinical and genetic approach in the characterization of newborns with anorectal malformation.

Objective: This study aimed to investigate clinical, surgical, and genetic data of neonates with anorectal malformation (ARM).

Study Design: A retrospective observational study was conducted on neonates with ARM as an isolated type (group 1), with ≤2 (group 2), and with ≥3 associated malformations (group 3), born between 2009 and 2020. Distribution of ARM, associated abnormalities and genetic testing were analyzed, and risk factors for adverse outcomes were identified.

An unusual neonatal case of reverse flow in the aortic arch and persistent pulmonary hypertension.

The reverse flow in the aortic arch in newborn is a rare finding due to congenital heart disease with blood "stealing" from the descending aorta or severe left ventricular outflow tract obstruction and to extracardiac abnormalities as systemic arteriovenous malformation. We describe a female newborn with unexpected reverse flow in the aortic arch due to severe persistent pulmonary hypertension (PPH). The presence of reverse flow in the aortic arch in PPH, secondary to compromised LV output, was rarely reported and investigated but can be a helpful sign of worse clinical course and poor prognosis.

Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation.

Background: Congenital pelvic skeletal anomalies (CPSA) may appear as isolated defects or in association with other anomalies like congenital malformations of the digestive system (CMDS). Minor CPSA in non-syndromic patients are often overlooked. We aimed to assess the frequency of CPSA in newborns with CMDS to review the diagnostic approaches.

Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience.

Objective: Methemoglobinemia (MetHb) is a rare congenital or acquired cause of infantile cyanosis. We examined the role of MetHb in a neonatal intensive care unit (NICU).

Study Design: A retrospective observational study was conducted reviewing blood gas analyses of hospitalized newborns over a 2-year period.