[Variations of the urinary pH values in a population of 13.000 patients addressing to the National Health System].

Aim: The regulation of the intra and extracellular pH-values plays an essential role in the metabolism of the human body. Whereas metabolic or respiratory acidosis or alkalosis, which include a deviation from the regular blood pH-range of 7.36 to 7.

The effect of colony stimulating factor-1 in vivo.

The present studies were undertaken to determine whether colony stimulating factor-1 (CSF-1) stimulates hemopoietic cell proliferation and differentiation in vivo. Groups of mice were injected with 25,000 units of pure, endotoxin-free L-cell CSF every 6 hours for intervals up to 8 days. Virtually no changes were detected in blood neutrophils or monocytes.

Regulation of diffusion-chamber granulopoiesis by colony-stimulating factor.

Studies were undertaken to examine the role of colony-stimulating factor (CSF) in controlling murine peritoneal diffusion-chamber (DC) granulopoiesis. Serum CSF was unchanged for 1-3 days after 700-750 rad total body irradiation. Variable increments were noted on the fourth and seventh days after irradiation.

Effect of anti-CSF on in vivo hemopoiesis.

Studies were undertaken to determine whether colony-stimulating factor in the serum is important in the control of granulopoiesis and monocytopoiesis. Groups of mice were injected with either antiserum to colony-stimulating factor (CSF) or normal rabbit serum every 12 h for intervals of 6-7 days. Antibody treatment did not lead to a reduction in circulating granulocytes or monocytes nor a decrease in marrow cellularity.