Publications by authors named "G Petzold"
Neuroinflammation in Alzheimer disease.
Nat Rev Immunol
December 2024
Article Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
Article Synopsis
- Patients who have suffered a stroke are at higher risk for developing post-stroke dementia, and the presence of serum anti-NMDA receptor autoantibodies (NMDAR1-abs) may negatively impact cognitive outcomes, particularly memory.
- In a study using the DEMDAS cohort, researchers found that 10.2% of stroke patients were seropositive for NMDAR1-abs, but this did not correlate with overall cognitive decline.
- However, those with NMDAR1-abs did show significantly worse performance in memory tasks and were more likely to experience memory impairment one year post-stroke, indicating a specific link between these autoantibodies and memory dysfunction.
Introduction: While incident ischemic lesions (IILs) are not unusual on follow-up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.
Methods: In a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.
Results: At 6 months, 78 patients (15.
Introduction: Endovascular thrombectomy (EVT) combined with intravenous thrombolysis is the current standard treatment for acute large-vessel occlusion stroke. Beyond clear clinical benefits in the acute and post-acute phases, comprehensive evaluations of long-term outcomes, including home and workforce reintegration, remain limited. This study aimed to assess home and workforce reintegration 1 year post-EVT in a cohort of acute stroke patients and explore their association with health-related quality of life (HRQoL).
View Article and Find Full Text PDFObjective: Predicting long-term functional outcomes shortly after a stroke is challenging, even for experienced neurologists. Therefore, we aimed to evaluate multiple machine learning models and the importance of clinical/radiological parameters to develop a model that balances minimal input data with reliable predictions of long-term functional independency.
Methods: Our study utilized data from the German Stroke Registry on patients with large anterior vessel occlusion who underwent endovascular treatment.