Data Science Methods and Tools for Industry 4.0: A Systematic Literature Review and Taxonomy.

The Fourth Industrial Revolution, also named Industry 4.0, is leveraging several modern computing fields. Industry 4.

Reliability and reproducibility analysis of the AOSpine Sacral Fractures Classification System by spinal and pelvic surgeons.

Study Design: Retrospective Cohort Study OBJECTIVES: The AOSpine Sacral Classification System was proposed as a comprehensive and universally accepted new classification for Sacral Fractures, and was recently internally validated. However, an external, independent and multidisciplinary reports on validation of this classification is lacking. Aim of the present study is to analyze the interobserver reliability and intraobserver reproducibility of the AOSpine Sacral Classification System for Sacral Fractures between orthopedic spinal and pelvic surgeons with different levels of experience.

A minimal physiologically based pharmacokinetic model for high-dose methotrexate.

Purpose: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally. HDMTX dosages are prescribed as a function of body surface area whereas dose adjustments depending on renal function are not well defined.

I4.0 Pilot Project on a Semiconductor Industry: Implementation and Lessons Learned.

Industry 4.0 considers the combinations of Internet of Things, computing and communication infrastructure, sensors, and artificial intelligence (AI) to provide predictive maintenance and process optimization. These benefits are very relevant to the semiconductor industry, where high reliability and low operating costs are critical for a business' success.

48 h for femur fracture treatment: are we choosing the wrong quality index?

Background: In the last 10 years, the rate of femur fractures treated within 48 h from trauma has been introduced as a performance index for hospital management in Italy. Literature showed a significant indirect correlation between early treatment and mortality/comorbidity. The aims of early treatment are pain management and reduction of time to ambulation.