Publications by authors named "G Pesarini"
Background: Early detection of cardiac allograft vasculopathy after heart transplant (HTx) with invasive coronary angiography is challenging.
Aims: The study aimed to determine if computational techniques able to assess epicardial lesions, by means of Murray's law-based quantitative flow ratio (μFR), and microvascular physiology, by means of angiography microvascular resistance (AMR), enhance risk stratification in HTx patients with nonsignificant coronary artery disease.
Methods: The cohort consisted of 86 consecutive HTx patients (200 epicardial vessels) with stenosis < 50% at baseline.
Article Synopsis
- This study examined how the physiological patterns of coronary artery disease (CAD) in patients with severe aortic stenosis (SAS) change before and after transcatheter aortic valve implantation (TAVI).* -
- It found that most patients had diffuse CAD, and vessels that showed a decrease in fractional flow reserve (FFR) post-TAVI had lower pre-TAVI measurements and exhibited significant gradients.* -
- Instantaneous wave-free ratio (iFR) changes were inconsistent, with both increases and decreases observed in vessels despite similar low pre-TAVI FFR and iFR values.*
Article Synopsis
- - The study investigates the impact of Diffuse Idiopathic Skeletal Hyperostosis (DISH) on the risk of Coronary Artery Disease (CAD), finding a significant association between DISH and higher CAD complexity.
- - Researchers analyzed data from 187 patients, identifying that 44.4% had DISH, which correlated with increased SYNTAX scores, indicating more severe CAD, independent of traditional risk factors.
- - Specifically, patients under 70 years with DISH had a sevenfold increased risk of severe CAD (SYNTAX score ≥34), suggesting that DISH could serve as a risk marker in cardiovascular assessments.
Despite significant goals achieved in diagnosis and treatment in recent decades, coronary artery disease (CAD) remains a high mortality entity and continues to pose substantial challenges to healthcare systems globally. After the latest guidelines, novel data have emerged and have not been yet considered for routine practice. The scope of this review is to go beyond the guidelines, providing insights into the most recent clinical updates in CAD, focusing on non-invasive diagnostic techniques, risk stratification, medical management and interventional therapies in the acute and stable scenarios.
View Article and Find Full Text PDFConcomitant aortic stenosis and coronary artery disease in the elderly population is frequent and the proper therapeutic approach is a matter of debate. We present 2 challenging cases of patients affected by severe aortic stenosis and chronic total occlusion of the left main, demonstrating the safety and feasibility of transcatheter aortic valve replacement, performed both with balloon-expandable and self-expanding valves.
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