Publications by authors named "G Perini"

The convergence of nanotechnology and tissue engineering has paved the way for innovative cancer treatments that leverage the unique light absorption properties of nanomaterials. Indeed, photothermal therapy (PTT) and photodynamic therapy (PDT) utilize nanomaterials to convert near-infrared light into therapeutic energy for cancer treatment. This study focuses on the application of poly(lactic--glycolic acid) (PLGA) scaffolds, enhanced by graphene oxide, TiCT MXene, and TiS transition metal dichalcogenides for PDT and PTT treatments evaluated within 3D-bioprinted breast cancers.

View Article and Find Full Text PDF
Article Synopsis
  • * Brexpiprazole is the only approved drug for agitation in Alzheimer's, but its effectiveness is questioned, and there are no approved treatments for psychosis, emphasizing the urgent need for new therapies.
  • * The review identifies three promising compounds in phase 3 trials for treating these symptoms: xanomeline-trospium for psychosis, and dextromethorphan-bupropion and dexmedetomidine for agitation; it also suggests incorporating biomarkers in clinical trials to improve drug testing efficiency.
View Article and Find Full Text PDF

Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma, predominantly afflicting older adults. There remains a notable absence of data regarding DLBCL in older adults in Latin America.

Materials And Methods: We conducted a retrospective analysis of 608 newly diagnosed Latin American patients with DLBCL aged ≥65 years.

View Article and Find Full Text PDF

Background: The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, the use of natural supplements has garnered attention for their potential in dementia prevention. Curcumin (Cur), derived from Curcuma longa, has demonstrated promising pharmacological effects against AD by reducing the levels of inflammatory mediators.

View Article and Find Full Text PDF

Fibroepithelial polyps (FEPs) are rare benign tumors that can occur in the urinary tract and are especially uncommon in the urethra. This report presents a case of a young man with obstructive symptoms caused by a urethral polyp, which was treated endoscopically. Fibroepithelial polyps can be a cause of urethral stenosis in young men and may also be encountered during the treatment of other causes of urethral narrowing.

View Article and Find Full Text PDF