Gene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii.

Motile cilia assembly utilizes over 800 structural and cytoplasmic proteins. Variants in approximately 58 genes cause primary ciliary dyskinesia (PCD) in humans, including the dynein arm (pre)assembly factor (DNAAF) gene DNAAF4. In humans, outer dynein arms (ODAs) and inner dynein arms (IDAs) fail to assemble motile cilia when DNAAF4 function is disrupted.

Food demand displaced by global refugee migration influences water use in already water stressed countries.

Millions of people displaced by conflicts have found refuge in water-scarce countries, where their perceived effect on water availability has shaped local water security discourses. Using an annual global data set, we explain the effects of refugee migrations on the host countries' water stress through the food demand displaced by refugees and the water necessary to produce that food. The water footprint of refugee displacement increased by nearly 75% globally between 2005 and 2016.

He Kāinga Oranga: reflections on 25 years of measuring the improved health, wellbeing and sustainability of healthier housing.

This paper reflects on the influences and outcomes of He Kāinga Oranga/Housing and Health Research Programme over 25 years, and their impact on housing and health policy in Aotearoa and internationally. Working in partnership particularly with Māori and Pasifika communities, we have conducted randomised control trials which have shown the health and broad co-benefits of retrofitted insulation, heating and remediation of home hazards, which have underpinned government policy in the Warm Up NZ-Heat Smart programme and the Healthy Homes Standards for rental housing. These trials have been included as evidence in the WHO Housing and Health Guidelines and led to our designation as a WHO Collaborating Centre on Housing and Wellbeing.

Bilateral Lesser Tuberosity Fractures: Technique and a Case Report with Literature Review.

Isolated lesser tuberosity fractures are a rare subset of proximal humerus fractures and are often associated with seizures. Displaced fractures can lead to chronic pain, reduced shoulder function, and posterior instability. Operative treatment is frequently recommended with the displacement of more than 5 mm or angulation of more than 45 degrees.