Publications by authors named "G Pemberton"
Article Synopsis
- The brown dog tick, Rhipicephalus sanguineus s.l., is a significant carrier of Rickettsia rickettsii, which causes Rocky Mountain spotted fever, prompting public health measures to control tick infestations around homes and on pets.
- Current control strategies primarily rely on acaricides, particularly synthetic pyrethroids, but many ticks have developed resistance to these chemicals, complicating prevention efforts.
- Researchers used advanced sequencing techniques to study genetic variations associated with acaricide resistance in different lineages of the tick, finding a specific genetic mutation tied to resistance that was commonly found in tropical lineage ticks across various locations in the US.
Local anesthesia enhanced with increasing high-frequency ultrasound intensity.
Drug Deliv Transl Res
October 2020
The effect of local anesthetics, particularly those which are hydrophilic, such as tetrodotoxin, is impeded by tissue barriers that restrict access to individual nerve cells. Methods of enhancing penetration of tetrodotoxin into nerve include co-administration with chemical permeation enhancers, nanoencapsulation, and insonation with very low acoustic intensity ultrasound and microbubbles. In this study, we examined the effect of acoustic intensity on nerve block by tetrodotoxin and compared it to the effect on nerve block by bupivacaine, a more hydrophobic local anesthetic.
View Article and Find Full Text PDFPurpose: Topical corneal local anesthetics are short acting and may impair corneal healing. In this study we compared corneal anesthesia and toxicity of topically applied -ethyl lidocaine (QX-314) versus the conventional local anesthetic, proparacaine (PPC).
Methods: Various concentrations of QX-314 and 15 mM (0.
In the version of this Article originally published, in Fig. 4f, the asterisk was missing; in Fig. 6a-c, the labels 'Wnt/β-catenin signalling', 'Wnt/Ca pathway' and 'ERK' and their associated lines/arrows were missing; and in Fig.
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