Publications by authors named "G Peluso"
Stimuli-responsive nanocomposite gels combine the unique properties of hydrogels with those of nanoparticles, thus avoiding the suboptimal results of single components and creating versatile, multi-functional platforms for therapeutic and diagnostic applications. These hybrid materials are engineered to respond to various internal and external stimuli, such as temperature, pH, light, magnetic fields, and enzymatic activity, allowing precise control over drug release, tissue regeneration, and biosensing. Their responsiveness to environmental cues permits personalized medicine approaches, providing dynamic control over therapeutic interventions and real-time diagnostic capabilities.
View Article and Find Full Text PDFSenescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP can induce senescence in healthy cells (secondary senescence), modulate immune system function, reshape the extracellular matrix, and facilitate cancer progression.Among SASP components, certain factors act as key regulators in the induction of secondary senescence.
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- * Researchers evaluated 80 patients in remission for at least six months using various clinical measures and performed ultrasound assessments on multiple joints and tendons to gauge synovitis and tenosynovitis.
- * Results showed that while clinical remission rates were higher in drug-free patients, ultrasonographic remission was more commonly observed among patients who were receiving treatment.
Article Synopsis
- The study evaluates a new technique called Delta Wave Automatic Mapping for effectively identifying ablation sites in patients with Wolff-Parkinson-White Syndrome (WPW) undergoing radiofrequency catheter ablation (RFCA).
- A total of 50 patients were analyzed, with all accessory pathways successfully ablated and a median time-to-effect of 2.0 seconds, showing no recurrences during a follow-up period of about 10 months.
- The workflow eliminates the need for manual site localization by leveraging existing algorithms, relying on specific historical electrical parameters to enhance ablation success and precision.
Plant-derived extracellular vesicles (EVs) have been recognized as important mediators of intercellular communication able to transfer active biomolecules across the plant and animal kingdoms. EVs have demonstrated an impressive array of biological activities, displaying preventive and therapeutic potential in mitigating various pathological processes. Indeed, the simplicity of delivering exogenous and endogenous bioactive molecules to mammalian cells with their low cytotoxicity makes EVs suitable agents for new therapeutic strategies for a variety of pathologies.
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