Publications by authors named "G Pathuri"
Bladder cancer (BCa) is one of the most lethal genitourinary malignancies owing to its propensity for recurrence and poor survival. The biochemical pathway, signal transducer and activator of transcription 3 (STAT3), has gained significance as a molecular pathway that promotes proliferation, invasion, and chemoresistance. In this study, we explored the targeting of STAT3 with TTI-101 and SH5-07 in BCa and elucidated the mechanisms in three-dimensional (3D) spheroid and organoid models.
View Article and Find Full Text PDFInflammation and obesity are two major factors that promote Colorectal cancer (CRC). Our recent data suggests that interleukin (IL)-23, is significantly elevated in CRC tumors and correlates with patient obesity, tumor grade and survival. Thus, we hypothesize that obesity and CRC may be linked via inflammation and IL-23 may be a potential target for intervention in high-risk patients.
View Article and Find Full Text PDFNon-steroidal anti-inflammatory drugs (NSAIDs) are promising colorectal cancer (CRC) chemopreventive drugs; however, to overcome NSAIDs' associated side effects, there is a need to develop safer and efficacious approaches. The present study was designed to evaluate (i) the efficacy of nitric-oxide releasing (NO)-Sulindac as compared to Sulindac; (ii) whether NO-Sulindac is superior to Sulindac in enhancing low-dose difluoromethylornithine (DFMO)-induced chemopreventive efficacy, and (iii) assessing the key biomarkers associated with colon tumor inhibition by these combinations. In F344 rats, colonic tumors were induced by azoxymethane (AOM).
View Article and Find Full Text PDFArticle Synopsis
- * Optimal and non-toxic doses of ONC201 were established through initial testing to ensure safety, allowing for subsequent efficacy studies without harmful side effects in the test subjects.
- * Treating mice with ONC201 significantly reduced both the incidence and number of intestinal tumors, with over 50% fewer colonic tumors and notable decreases in small intestinal polyps, indicating ONC201's strong anti-cancer potential.
Article Synopsis
- - Indian gooseberry, known from traditional Ayurvedic medicine, is valued for its therapeutic properties and uses various parts of the plant to treat different diseases.
- - Research shows that gooseberry can prevent cancer in rodent models by reducing tumor incidence and volume and working through mechanisms like antioxidant activity and inflammation regulation.
- - Human studies suggest that gooseberry may provide health benefits and enhance the effectiveness of other treatments, with ongoing clinical trials exploring its potential as an anti-cancer agent.