Fabrication of Oro-Dispersible Sodium Valproate-Loaded Nanofibrous Patches for Immediate Epileptic Innervation.

Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has been employed for prophylactic management; however, oral administration is not applicable for critical scenarios, thus calling for medication routes fulfilling necessities of immediate innervation.

Vitamin B-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B.

Alzheimer's disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to 131 million by 2050. Investigations suggested the existence of a direct proportion between the likelihood of AD occurrence and vitamin B (VB) hypovitaminosis.

Preparation and mechanical properties of graphene oxide: cement nanocomposites.

We investigate the performance of graphene oxide (GO) in improving mechanical properties of cement composites. A polycarboxylate superplasticizer was used to improve the dispersion of GO flakes in the cement. The mechanical strength of graphene-cement nanocomposites containing 0.

[Vasectomy in Quebec: 1977-1997].

Vasectomy is recognized as an efficient method of contraception. However, some recent findings have suggested that vasectomy may raise a potential health risk, notably related to prostate cancer. The goal of the present study is to evaluate the spatial and temporal evolution of this surgical practice in Québec (Canada).