Publications by authors named "G Paraskevas"
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.
View Article and Find Full Text PDFPurpose: We performed a scoping review to explore if ChatGPT, an artificial intelligence platform, can play a significant role in anatomy education.
Methods: PubMed, SCOPUS, ERIC and Cochrane databases were searched for articles which included anatomical questions asked to ChatGPT. From each article, we extracted the following data: authors, type of study (qualitative or quantitative), presence or not of comparison of ChatGPT with other platforms or humans, type of questions asked to ChatGPT and evaluation of the answers to these questions.
: Alzheimer's disease (AD) may present with pure (typical or atypical) and mixed phenotypes, sometimes causing difficulties in (differential) diagnosis. In order to achieve a diagnostic accuracy as high as possible, the diagnosis of AD during life depends on various biomarkers, including the cerebrospinal fluid (CSF) biomarkers. : Classical CSF AD biomarkers were determined in a total of 61 patients, classified as both beta amyloid- and tau-positive AT (or AT according to the recently revised Alzheimer Association criteria for diagnosis and staging of AD).
View Article and Find Full Text PDFCognitive impairment represents a core and prodromal clinical feature of cerebral amyloid angiopathy (CAA). We sought to assess specific cognitive domains which are mainly affected among patients with CAA and to investigate probable associations with neuroimaging markers and Cerebrospinal Fluid (CSF) biomarkers. Thirty-five patients fulfilling the Boston Criteria v1.
View Article and Find Full Text PDFFinite element analysis of the knee joint: a computational tool to analyze the combined behavior after treatment of torn ligaments and menisci in the human knee joint.
SICOT J
October 2024
Article Synopsis
- Finite element analysis (FEA) is crucial in orthopaedics for simulating and analyzing surgical procedures, revealing that removing over 20% of the meniscus significantly raises shear stress in cartilage and heightens knee joint degeneration risk.
- Meniscal root repair can enhance meniscal biomechanics and lower osteoarthritis risk, even with non-ideal repairs, while FEA helps to study the biomechanics of knee ligaments, showing that certain graft techniques closely mimic native knee function.
- Incorporating lateral augmentation techniques can enhance stability in ACL and PCL repairs, and there is a need for future studies to integrate patient-specific anatomical and mechanical data for better experimental models.