Publications by authors named "G Papenberg"
Article Synopsis
- Recent studies showed only weak connections between age, dopamine receptor availability, and cognitive decline, suggesting more research is needed.
- Longitudinal data over five years found that older adults who experienced declines in D2/3 dopamine receptors had worse working memory performance over time.
- Specifically, the decline in dopamine receptor availability was significant in key brain regions linked to working memory, supporting the idea that dopamine changes contribute to cognitive aging.
Article Synopsis
- A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
- The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
- While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
Iron is necessary for many neurobiological mechanisms, but its overaccumulation can be harmful. Factors triggering age-related brain iron accumulation remain largely unknown and longitudinal data are insufficient. We examined associations between brain iron load and accumulation and, blood markers of iron metabolism, cardiovascular health, lifestyle factors (smoking, alcohol use, physical activity, diet), and ApoE status using longitudinal data from the IronAge study (n = 208, age = 20-79, mean follow-up time = 2.
View Article and Find Full Text PDFObjective: Diabetes is a well-known risk factor for dementia. We investigated the association between (pre)diabetes and older brain age and whether this can be attenuated by modifiable lifestyle behaviors.
Research Design And Methods: The study included 31,229 dementia-free adults from the UK Biobank between the ages of 40 and 70 years.
Article Synopsis
- Cognitive reserve (CR) influences the risk of depression and its progression to dementia or death, with a study examining over 436,000 participants to explore these relationships.
- Those with high CR showed a significantly lower risk of developing depression, subsequent dementia, and mortality compared to those with low CR.
- The results suggest that increasing CR can extend the time individuals remain depression-free, emphasizing its importance in mental health prevention strategies.