The Neurophysiological Impact of Touch-Based Therapy: Insights and Clinical Benefits.

The evidence on how touch-based therapy acts on the brain activity opens novel cues for the treatment of chronic pain conditions for which no definitive treatment exists. Touch-based therapies, particularly those involving C-tactile (CT)-optimal touch, have gained increasing attention for their potential in modulating pain perception and improving psychological well-being. While previous studies have focused on the biomechanical effects of manual therapy, recent research has shifted towards understanding the neurophysiological mechanisms underlying these interventions.

Availability and quality assessment of Clinical Practice Guidelines on orthoplastic surgery treatment of open fractures of the lower limb using AGREE II tool: A systematic review.

Introduction: Orthoplastic surgery, which combines orthopedic and plastic surgery principles, plays a crucial role in the treatment of open fractures of the lower limb. Clinical Practice Guidelines (CPGs) are valuable tools for standardizing and improving patient care.

Objective: To assess the availability and quality of international CPGs for orthoplastic treatment of open fractures of the lower limb.

BEEHIVE: A dataset of Apis mellifera images to empower honeybee monitoring research.

This data article describes the collection process of two sub-datasets comprehending images of Apis mellifera captured inside a commercial beehive ("Frame" sub-dataset, 2057 images) and at the bottom of it ("Bottom" sub-dataset, 1494 images). The data was collected in spring of 2023 (April-May) for the "Frame" sub-dataset, in September 2023 for the "Bottom" sub-dataset. Acquisitions were carried out using an instrumented beehive developed for the purpose of monitoring the colony's health status during long periods of time.

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function.

Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here, we describe a therapeutic strategy called "RING-Bait," which employs an aggregating protein sequence combined with an E3 ubiquitin ligase.

Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication.

Organisms respond to proteotoxic-stress by activating the heat-shock response, a cellular defense mechanism regulated by a family of heat-shock factors (HSFs); among six human HSFs, HSF1 acts as a proteostasis guardian regulating severe stress-driven transcriptional responses. Herein we show that human coronaviruses (HCoV), both low-pathogenic seasonal-HCoVs and highly-pathogenic SARS-CoV-2 variants, are potent inducers of HSF1, promoting HSF1 serine-326 phosphorylation and triggering a powerful and distinct HSF1-driven transcriptional-translational response in infected cells. Despite the coronavirus-mediated shut-down of the host translational machinery, selected HSF1-target gene products, including HSP70, HSPA6 and AIRAP, are highly expressed in HCoV-infected cells.