Publications by authors named "G Pano"

Collagen remodeling contributes to many physiologic and pathologic processes. In primary tumors, the linearization of collagen fibers promotes cancer cell invasion and metastasis and is indicative of poor prognosis. However, it remains unknown whether there are endogenous inhibitors of collagen linearization that could be exploited therapeutically.

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Brightly colored manakin (Aves: Pipridae) males are known for performing acrobatic displays punctuated by non-vocal sounds (sonations) in order to attract dull colored females. The complexity of the display sequence and assortment of display elements involved (e.g.

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Article Synopsis
  • - Collagen linearization, which is associated with aggressive tumors, enhances cancer cell invasion and metastasis, and this process can occur without mechanical forces from the cells.
  • - The study identifies WISP1 (CCN4), a matricellular protein secreted by tumor cells, as a crucial factor that binds to type I collagen, leading to its linearization in both cell-free and tumor environments.
  • - Increased levels of WISP1 in patient tumors are linked to quicker progression of cancer and poorer patient outcomes, highlighting its role in promoting metastasis through collagen linearization.
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1. This work examined the effect of using three different feeding regimens in the prophylaxis and treatment of ascites in fastgrowing broilers stressed by exposure to cold (less than 10 degrees C), itself a potent inducer of ascites. 2.

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An experimental feeding trial was conducted in order to substantiate an hypothesis on the aetiology of a previously unrecorded cardiomyopathic syndrome in beef cattle in Israel. It was believed that residues of the ionophore maduramicin (Cygro; American Cyanamid) in poultry litter fed to cattle, after the maduramicin had been incorporated into broiler feed as a coccidiostat, were the cause of the cardiomyopathy. Three groups of 5 heifers were fed for several weeks (1) poultry litter from a field case, containing 4.

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