Luminescent terbium(III) probes containing an aromatic amino acid-based antenna for discrimination between adenine and guanine nucleotides.

Herein we present a series of luminescent Tb(III)-probes ([Tb-Ltrp], [Tb-Ltyr], and [Tb-Lphe]) for sensing and discriminating purine nucleoside polyphosphates (NPP) based on a modified DTTA chelator appended to aromatic amino acids (Laa). The optically most effective luminescent [Tb-Ltrp] probe preferentially discriminates the guanine-NPPs over the adenine-NPPs PeT-based modulation of Tb(III) luminescence within the biological concentration range.

NaBSiSe: a novel B-cluster-containing quaternary selenoborate framework material.

We report the successful synthesis of the new quaternary, three-dimensional NaSiBSe material using a solid-state synthesis route. This compound is characterized by a unique framework structure that features the rare icosahedral [B] cation which is connected SiSe polyhedral units into a 3D framework structure with Na ions located inside the channels. The NaSiBSe compound crystallizes in the cubic crystal system in the space group 3̄, with lattice parameter = 11.

Synthesis, Optical, and Magnetic Properties of the Mixed Chalcogenide Semiconductor Series Eu(II)SiSeS, Prepared via the Flux-Assisted Boron Chalcogen Mixture Method.

We report a detailed structural study of a series of five new quaternary Eu(II)-containing mixed chalcogenide phases, EuSiSeS, EuSiSeS, EuSiSeS, EuSiSeS, and EuSiSe, synthesized using the flux-assisted boron chalcogen mixture (BCM) method. High-quality crystals were grown, and their crystal structures were determined by single-crystal X-ray diffraction. All members of the EuSiSeS series crystallize in the monoclinic crystal system with space group 2/, except EuSiSe, which crystallizes in the 2 space group.

Nonsense-mediated mRNA decay: Physiological significance, mechanistic insights and future implications.

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades premature aberrant transcripts and importantly, it also takes part in gene expression regulation by regulating the endogenous transcripts. NMD distinguishes aberrant and non-aberrant transcript by looking after the NMD signatures such as long 3' UTR. NMD modulates cellular surveillance and eliminates the plausible synthesis of truncated proteins as because if the aberrant mRNA escapes the surveillance pathway it can lead to potential negative phenotype resulting in genetic diseases.

Nonsense-Mediated mRNA Decay in Human Health and Diseases: Current Understanding, Regulatory Mechanisms and Future Perspectives.

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that is conserved across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA (mRNA) harbouring premature stop codons. It regulates the gene expression by targeting aberrant mRNA carrying pre-termination codons (PTCs) and eliminates C-terminal truncated proteins. NMD distinguishes aberrant and non-aberrant transcript by looking after long 3' UTRs and exon-junction complex (EJC) downstream of stop codon that indicate the presence of PTC.