Publications by authors named "G Palenzuela"
Background: Medulloblastoma (MB) is one of the most prevalent embryonal malignant brain tumors. Current classification organizes these tumors into four molecular subgroups (WNT, SHH, Group 3, and Group 4 MB). Recently, a comprehensive classification has been established, identifying numerous subtypes, some of which exhibit a poor prognosis.
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- - The SIOP-CNS-GCT-II European trial studied the effects of age on acute toxicity from chemotherapy in patients with central nervous system germ cell tumors, using various chemotherapy regimens based on tumor type.
- - Analysis included 296 patients across three age groups: children (≤11 years), adolescents (12-17 years), and adults (≥18 years), revealing that adults experienced lower rates of severe adverse events compared to adolescents despite similar chemotherapy dosages.
- - The study concluded that adults can safely tolerate intensive chemotherapy protocols with less toxicity than adolescents, indicating a need for further investigation into how age influences chemotherapy-related toxicity.
Article Synopsis
- High-risk medulloblastomas (HR-MB) show varied responses to initial chemotherapy, leading to a study on the effectiveness of continued treatment or changes in strategy for patients with stable or progressively worsening conditions.
- A retrospective analysis of 49 HR-MB patients revealed that those with stable disease (37 patients) had significantly better outcomes compared to those with progressive disease (12 patients), particularly in terms of 5-year progression-free survival (PFS) and overall survival (OS).
- The results suggest that patients with stable disease can benefit from continued treatment (tandem high-dose chemotherapy and craniospinal irradiation), while those with progressive disease may need new treatment options, as their survival rates were significantly lower.
Purposes: The purpose of this study was to retrospectively study embryonal tumors with multilayered rosettes (ETMR), a rare new entity that gathers ETAN-TR (embryonal tumor with abundant neuropil and true rosettes), ependymoblastomas, and medulloepitheliomas, in order to improve their descriptions and try to better define therapeutic modalities.
Methods: Patients with ETMR, ETAN-TR, ependymoblastoma, and medulloepithelioma treated in SFCE centres (Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'adolescent) since 2000 were collected. Data were retrieved from clinical charts.