Publications by authors named "G Palazzini"

Early-onset systemic lupus erythematous (SLE) is a distinct clinical entity characterized by the onset of disease manifestations during childhood. Despite some similarities to patients who are diagnosed during adulthood, early-onset SLE typically displays a greater disease severity, with aggressive multiorgan involvement, lower responsiveness to classical therapies, and more frequent flares. Lupus nephritis is one of the most severe complications of SLE and represents a major risk factor for long-term morbidity and mortality, especially in children.

View Article and Find Full Text PDF
Article Synopsis
  • * The study focuses on three children with monogenic systemic lupus erythematosus (SLE) due to DNASE1L3 variants who experienced severe kidney issues, showing different types of glomerulonephritis.
  • * Findings revealed a connection between DNASE1L3-related kidney issues and interferon signaling, suggesting potential benefits of targeted interferon therapies to improve patient outcomes.
View Article and Find Full Text PDF

Intradialytic hypotension (IDH) is a frequent and well-known complication of hemodialysis, occurring in about one third of patients. An integrated approach with different methods is needed to minimize IDH episodes and their complications. In this prospective observational study, recruited patients underwent a multiparametric evaluation of fluid status through a lung ultrasound (LUS) with the quantification of B-lines, a physical examination, blood pressure, NT-proBNP and chest X-rays.

View Article and Find Full Text PDF

Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the gastrointestinal tract from the duodenum to the rectum. The clinical condition is entirely asymptomatic in many patients, particularly with small cysts. The diagnosis is typically incidental and secondary to imaging performed for other purposes.

View Article and Find Full Text PDF