Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.

The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines.

Latreille (Diptera, Ceratopogonidae) of Colombia: records from the collection of insects of medical importance from National Institute of Health.

Background: The collection of insects of medical importance from the Instituto Nacional de Salud, INS (Bogotá, Colombia: https://www.ins.gov.

Electrical bioimpedance analysis and comparison in biological tissues through crystalloid solutions implementation.

Electrical bioimpedance is a non-invasive and radiation-free technique that was proposed to be used in different clinical areas, however, its practical use is limited due to its low capacity to discriminate between tissues. In order to overcome this limitation, our research group proposes to incorporate the contrast media into the electrical bioimpedance procedure. The main objective of the present study was to assess the crystalloid solutions as a possible contrast media to discriminate between different tissue types in the bioimpedance technique.

Wavelength-stepping algorithm for testing the thickness and front and back surfaces of optical plates with high signal-to-noise ratio.

We propose a least-squares phase-stepping algorithm (LS-PSA) consisting of only 14 steps for high-quality optical plate testing. Optical plate testing produces an infinite number of simultaneous fringe patterns due to multiple reflections. However, because of the small reflection of common optical materials, only a few simultaneous fringes have amplitudes above the measuring noise.

Applying GST to Understand and Contextualize Bullying: A Conjunctive Analysis of Case Configurations.

Drawing from Agnew's general strain theory, this study examines whether certain risk factors have a consistent effect across different situational contexts that characterize bullying perpetration. A conjunctive analysis of case configurations was conducted to examine and identify situational factors that increase adolescents' risks for bullying perpetration using data from the 2019 Minnesota Student Survey. Results from a sample of 166,176 U.