Combined Mitraclip Redo and Triclip Transcatheter Edge-to-Edge Repair Using Triclip Guide Catheter: A Case Report Demonstrating Its Feasibility.

A 76-year-old female patient with a previous Mitraclip implant presented with worsening heart failure signs and symptoms. Moderate to severe Mitral regurgitation and severe Tricuspid regurgitation was diagnosed. We present a case of combined redo Mitraclip and Triclip transcatheter edge-to-edge repair using Triclip guide catheter for both procedures.

Novel Oxadiazole-Quinoxalines as Hybrid Scaffolds with Antitumor Activity.

A small library of 25 novel 1,3,4-oxadiazole-quinoxalines was synthesized and evaluated in vitro for its cytotoxic activity at 10 μM concentration against nine NCI-different cancer cell lines. Among tested compounds, derivatives , , and showed good inhibition percentages over different cell lines and, therefore, progressed to the full five-dose assay. Compound , possessing a 1,3,4-oxadiazole-core, bearing a 7-trifluoromethyl-quinoxaline nucleus on C-2 and a C-5 phenyl ring, had activity against leukemia, CNS, ovarian, renal, prostate, and breast cancer, with highest the values against breast MCF7 (GI: 1.

Harmful epistemic dependence on medical machine learning and its moral implications.

The advances in machine learning (ML)-based systems in medicine give rise to pressing epistemological and ethical questions. Clinical decisions are increasingly taken in highly digitised work environments, which we call artificial epistemic niches. By considering the case of ML systems in life-critical healthcare settings, we investigate (1) when users' reliance on these systems can be characterised as epistemic dependence and (2) how this dependence turns into what we refer to as harmful epistemic dependence of clinical professionals on medical ML.

Folate metabolism in myelofibrosis: a missing key?

Folates serve as key enzyme cofactors in several biological processes. Folic acid supplementation is a cornerstone practice but may have a "dark side". Indeed, the accumulation of circulating unmetabolized folic acid (UMFA) has been associated with various chronic inflammatory conditions, including cancer.

Role of the Southern Annular Mode in the sea level over the southern Blue Amazon.

Regional sea level rise varies from the global average and is influenced by climate variability. We studied sea level anomalies in southern Brazil from 1993 to 2022, finding increasing trend from 1993 to 2022. We used oceanic and atmospheric dynamics to understand the rapid sea level rise.