A novel quantitative trait locus for barley yellow dwarf virus resistance and kernel traits on chromosome 2D of a wheat cultivar Jagger.

Barley yellow dwarf (BYD) is one of the most serious viral diseases in cereal crops worldwide. Identification of quantitative trait loci (QTLs) underlining wheat resistance to barley yellow dwarf virus (BYDV) is essential for breeding BYDV-tolerant wheat cultivars. In this study, a recombinant inbred line (RIL) population was developed from the cross between Jagger (PI 593688) and a Jagger mutant (JagMut1095).

Nrf2/HO-1 Pathway Mediated Protective Effects of Hydrogen in a Model of Lung Transplantation Simulated by Rat Pulmonary Microvascular Endothelial Cells.

This study aimed to observe the mechanism of hydrogen (H) in a lung transplantation model simulated by pulmonary microvascular endothelial cells (PMVECs), which were divided into 5 groups. The blank group was the normal PMVECs. During cold ischemia period, PMVECs in the control, O, or H groups were aerated with no gas, O, or 3% H, and 3% H after transfected with a small interfering RNA targeting Nrf2 in the H+si-Nrf2 group.

Five New Indole Alkaloid Derivatives from Deep-Sea Fungus AF1.

One new gliotoxin derivative fumianthrogliotoxin (), one new indoquizoline alkaloid 3-(methyl propionate) indoquizoline (), and three novel indole alkaloids, anthroxyindole (), (±)-asperfumiindole A (), and (±)-asperfumiindole B (), together with 16 known compounds (-), were isolated from the culture of deep-sea derived fungus AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds - and - were evaluated for anti-pulmonary fibrosis activity.

Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin/Utrophin Double-Knockout Mice.

Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease occurring due to mutations of the dystrophin gene. There is no cure for DMD. Using a dystrophinutrophin (DKO-Hom) mouse model, we investigated the PGE2/EP2 pathway in the pathogenesis of dystrophic muscle and its potential as a therapeutic target.