[Yeast secretory heat-shock proteins: a new family of stress proteins?].

The overwhelming majority of presently known heat shock proteins are associated with cells. These proteins are localized nearly in practically all subcellular compartments and perform a diversity of functions, including control over folding and translocations of proteins their folding, formation of oligomeric complexes, etc. Besides, these proteins determine the thermal tolerance of cells.

[A prosegment of the yeast alpha-factor controls a heterologous protein (human growth factor) in Saccharomyces cerevisiae culture media].

The role of the yeast pheromone prosegment--alpha-factor--in the export of the heterologous protein, the human growth hormone (hGH), in the culture medium of S. cerevisiae has been studied. Using genetic engineering constructions, it has been shown that different N-terminal signal peptides (SP) are not able to provide the hGH export.