CLEC11A methylation is correlated to AML subtypes and cytogenetic risk factors but not patient demographics.

Acute myeloid leukemia (AML) is an aggressive and lethal cancer of the blood, which leads to the death of over 11,000 patients in the United States each year. Research on identifying, characterizing, and treating AML is crucial in the fight against this deadly disease. Recent studies have examined the role of CLEC11A in cancer, including AML.

"Self-care is being attentive to yourself": using assemblages to examine discursive-material practices of self-care among Filipino university students.

Purpose: Researchers have observed a rise in mental health issues among university students over the course of the pandemic, in part due to the closure of schools and public spaces for wellness. Thus, the purpose of this study is to explore how students creatively reassemble their self-care practices through different objects and spaces within their homes to care for their mental health.

Methods: Photo-elicitation interviews were conducted with ten (10) female university students from the Philippines.

Bodies-in-waiting as infrastructure: Assembling the Philippine Government's disciplinary quarantine response to COVID-19.

The purpose of this article is to advance the concept of bodies-in-waiting as an everyday infrastructure to explain the shifting nature of 'pandemic cities' in response to the changing dynamics of infection control in urban spaces. While previous literatures have been 'sanitized' to emphasize the importance of managing optimal physiological health and safety, we would like to argue that keener attention is needed to rethink the constitutive role of bodies in co-producing a city's sociopolitical ecologies at this time of crisis. The main body is divided into three sections.

Selective activity against proliferating tumor endothelial cells by CVX-22, a thrombospondin-1 mimetic CovX-Body.

CVX-22 is a CovX-Body, produced by covalently attaching a thrombospondin-1 (TSP-1) type 1 repeat peptide mimetic to a humanized IgG1 molecule. To dissect the antiangiogenic mechanism of CVX-22, the numbers and proliferative status of defined tumor endothelial cell (TEC) subsets from the B16 and C32 melanoma models were examined. CVX-22 treatment reduced the numbers of activated, vascular endothelial growth factor receptor 2 (VEGFR2)-positive TECs.

Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.

Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagonists in vitro and had antitumor efficacy in a prostate cancer xenograft model which, on a molar basis, far exceeded the activity of the parent small molecule.