Publications by authors named "G P Prevost"
Aim: To investigate the evolution of the incretin-like peptide 26RFa in a prospective cohort of women living with obesity with or without type 2 diabetes (T2D) before and after sleeve gastrectomy (SG).
Methods: In this study, a total of 61 women were divided into three groups: women living with severe obesity without T2D (WlwOB group), women living with severe obesity and T2D (WlwOB-T2D group) and lean healthy volunteers (control group). Serum 26RFa concentrations were measured using a 26RFa enzyme-linked immunosorbent assay developed specifically for this study during meal tests before SG, and 30 and 180 days after SG.
Article Synopsis
- * The study utilizes over 20 years of structural data from the Protein Data Bank to examine neomycin B and kanamycin A, focusing on how the structure of these antibiotics is used by modifying enzymes.
- * A thorough comparison of different enzymes and their interaction with the RNA A-site target revealed shared traits in how these enzymes recognize antibiotics, while also evaluating the adaptability of neomycin B and kanamycin A in different settings.
Introduction: In acute obstructive common bile duct (CBD) stones endoscopic retrograde cholangiography for CBD stone removal before cholecystectomy (ChE) ('ERC-first') is the gold standard of treatment. Intraoperative antegrade balloon dilatation of the duodenal papilla during ChE with flushing of CBD stones to the duodenum ('ABD-during-ChE') may be an alternative 'one-stop-shop' treatment option. However, a comparison of outcomes of the 'ABD-during-ChE' technique and the'ERC-first' approach has never been performed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the varying glycaemic profiles in individuals with type 1 diabetes to better understand their complexities.
- Using a unique methodology and the DDRTree algorithm, researchers identified seven distinct glycaemic phenotypes among 618 participants.
- The findings suggest that relying solely on traditional metrics may overlook important subtleties of glycaemic management, emphasizing the need for more tailored strategies in treatment.*
Background: Obesity and type 2 diabetes are strongly associated pathologies, currently considered as a worldwide epidemic problem. Understanding the mechanisms that drive the development of these diseases would enable to develop new therapeutic strategies for their prevention and treatment. Particularly, the role of the brain in energy and glucose homeostasis has been studied for 2 decades.
View Article and Find Full Text PDF