[The activity of blood and urinary enzymes in patients with osteoarthrosis deformans and a drug-induced kidney lesion during indomethacin treatment].

A study is presented of 40 patients suffering of osteoarthrosis deformans and treated for 21 days with indomethacin (100 mg daily). Determination of the dynamics of enzymatic activity sorbit dehydrogenase, alkaline phosphatase, gamma-glutamyltranspeptidase in the blood serum and urine were used as criteria of early diagnosis of drug-induced nephropathy due to indomethacin treatment.