Publications by authors named "G P Marone"
The Epithelial Science Expert Group convened on 18-19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research, the evolution of asthma management throughout the ages was discussed and the role of the epithelium as an immune-functioning organ was elucidated.
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- Neutrophils, the most common type of white blood cells, play a significant role in inflammation and are present in greater levels in patients with psoriatic arthritis (PsA), a chronic disease affecting joints and other body systems.
- A study involving 31 PsA patients and 22 healthy controls investigated the function of neutrophils from blood samples; these neutrophils were tested for various activation and response characteristics.
- Results showed that neutrophils from PsA patients had lower activation and effectiveness when responding to stimuli, along with elevated serum levels of inflammatory markers, suggesting a compromised immune response in these patients.
Introduction: The Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of transcription (STAT). JAK-STAT5 pathways play a critical role in basophil and mast cell activation.
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- Hereditary angioedema (HAE) is a rare genetic disorder causing episodes of swelling, particularly due to an increase in a substance called bradykinin, especially in patients with mutations in the F12 gene that affect C1 inhibitor activity.
- A study comparing 40 patients with FXII-HAE to 40 healthy individuals found increased plasma levels of specific lipid mediators and enzymes, indicating an altered biochemical response in those with the condition.
- The findings suggest that the overproduction of bradykinin impacts certain pathways in FXII-HAE, opening up potential avenues for further research on the role of these lipid mediators in the disease.
Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve, and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a broad spectrum of vasoactive and proinflammatory mediators, which have potential roles in inflammation, angiogenesis, lymphangiogenesis, tissue remodelling, and fibrosis. Mast cells release preformed mediators (e.
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