Guideline-Based Follow-Up Outcomes in Patients With Gastrointestinal Stromal Tumor With Low Risk of Recurrence: A Report From the Italian Sarcoma Group.

Importance: Gastrointestinal stromal tumor (GIST) follow-up is recommended by international guidelines, but data on the role of follow-up in patients with low relapse risk are missing. For these patients, the potential benefit of anticipating recurrence detection should be weighed against psychological burden and radiologic examination loads in terms of costs and radiation exposure.

Objective: To evaluate the outcomes of guideline-based follow-up in low-risk GIST.

Targeting cyclin-dependent kinases in sarcoma treatment: Current perspectives and future directions.

Effective treatment of advanced/metastatic bone and soft tissue sarcomas still represents an unmet medical need. Recent advances in targeted therapies have highlighted the potential of cyclin-dependent kinases (CDK) inhibitors in several cancer types, including sarcomas. CDKs are master regulators of the cell cycle; their dysregulation is listed among the "hallmarks of cancer" and sarcomas are no exception to the rule.

SECONDARY NEUTRON DOSES IN A PROTON THERAPY CENTRE.

The formation of secondary high-energy neutrons in proton therapy can be a concern for radiation protection of staff. In this joint intercomparative study (CERN, SCK•CEN and IBA/IRISIB/ULB), secondary neutron doses were assessed with different detectors in several positions in the Proton Therapy Centre, Essen (Germany). The ambient dose equivalent H(*)(10) was assessed with Berthold LB 6411, WENDI-2, tissue-equivalent proportional counter (TEPC) and Bonner spheres (BS).

A Bonner Sphere Spectrometer for pulsed fields.

The use of conventional Bonner Sphere Spectrometers (BSS) in pulsed neutron fields (PNF) is limited by the fact that proportional counters, usually employed as the thermal neutron detectors, suffer from dead time losses and show severe underestimation of the neutron interaction rate, which leads to strong distortion of the calculated spectrum. In order to avoid these limitations, an innovative BSS, called BSS-LUPIN, has been developed for measuring in PNF. This paper describes the physical characteristics of the device and its working principle, together with the results of Monte Carlo simulations of its response matrix.

A new version of the LUPIN detector: improvements and latest experimental verification.

LUPIN-II is an upgraded version of LUPIN, a novel rem counter first developed in 2010 specifically conceived to work in pulsed neutron fields (PNFs). The new version introduces some modifications that improve the performance of the detector, in particular extending its upper detection limit in PNFs. This paper discusses the characteristics and the performance of the instrument.