Publications by authors named "G P Leese"
Background: Findings from cardiovascular outcome trials suggest that fenofibrate therapy may reduce the progression of diabetic retinopathy.
Methods: We recruited and followed adults with nonreferable diabetic retinopathy or maculopathy using the national Diabetic Eye Screening (DES) program in Scotland. We randomly assigned participants to receive 145-mg fenofibrate tablets or placebo (taken daily or, in those with impaired renal function, on alternate days).
Article Synopsis
- A genome-wide association study was conducted on thyroid function, analyzing data from up to 271,040 European individuals, focusing on hormones like TSH, FT4, and T3.
- The study identified 259 significant genetic associations for TSH (61% were novel), and notable findings for FT4 and T3, indicating that specific genes influence thyroid hormone levels and metabolism.
- The research findings enhance the understanding of thyroid hormone roles and suggest that variations in thyroid function may impact various health conditions including cardiovascular issues, autoimmune diseases, and cancer.
Article Synopsis
- Diabetic retinopathy (DR) is a severe eye complication linked to diabetes, driven by systemic inflammation and oxidative stress; the neutrophil-lymphocyte ratio (NLR) serves as a potential indicator of immune activity and may predict DR incidence.
- A study analyzed data from over 23,000 individuals with type 2 diabetes to assess the impact of NLR on developing DR, using advanced statistical models to account for factors like mortality.
- The findings revealed that a higher NLR (optimal cut-off at 3.04) correlated with increased risk of DR, with 35.8% of subjects developing the condition over 10 years, indicating NLR's significance as a prognostic biomarker in diabetes-related eye health
Stable Incidence and Increasing Prevalence of Primary Hyperparathyroidism in a Population-based Study in Scotland.
J Clin Endocrinol Metab
September 2023
Context: Previous studies, including our own, have demonstrated a highly variable incidence of primary hyperparathyroidism (PHPT) from year to year.
Objective: We planned to provide a current estimate of the incidence and prevalence of PHPT in a community-based study.
Methods: A population-based retrospective follow-up study was conducted in Tayside (Scotland) from 2007 to 2018.
Context: Primary hyperparathyroidism (PHPT) is associated with increased risk of morbidity and death, and vitamin D levels are a potentially confounding variable.
Objective: The aim of this study was to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT).
Methods: In this population-based retrospective matched cohort study, data linkage of biochemistry, hospital admissions, prescribing, imaging, pathology, and deaths was used to identify patients across the region of Tayside, Scotland, who had PHPT from 1997 to 2019.