Publications by authors named "G P Huffman"
Objective: We aimed to assess the recent trends in the demographics of radial head and neck fractures and their management based on displacement.
Methods: TriNetX was queried for cases from 1 January 2017, through 31 December 2022. ICD diagnosis codes were used to define patient cohorts with radial head or neck fractures.
Background: Worldwide, hepatocellular carcinoma (HCC) is the second most lethal cancer, although early-stage HCC is amenable to curative treatment and can facilitate long-term survival. Early detection has proved difficult, as proteomics, transcriptomics, and genomics have been unable to discover suitable biomarkers.
Methods: To find new biomarkers of HCC, we utilized a spatial omics N-glycan imaging method to identify altered glycosylation in cancer tissue (n = 53) and in paired serum of individuals with HCC (n = 23).
Massive rotator cuff tears constitute approximately 20% of all rotator cuff tears. Poor tissue quality or significant retraction can lead to failure of the repair. The anterior rotator cuff cable is essential in transmitting force to the proximal humerus and serves as the main load-bearing structure within the supraspinatus.
View Article and Find Full Text PDFBackground Fractures of the humerus are one of the more common fractures in the United States and a cause of fragility fractures in the elderly population. This study aims to understand recent trends in the demographic factors correlated with humeral shaft fractures (HSF) and humeral shaft fracture nonunion (HSFN) following open reduction internal fixation (ORIF) and intramedullary nailing (IMN). Methods The TriNetX database was used to query using International Classification of Diseases-10 (ICD10) diagnosis codes for patients who sustained HSF between 2017 and 2022.
View Article and Find Full Text PDFArticle Synopsis
- Pre-patterning in embryo development is common in non-mammalian species, but mammals were thought to lack this due to their regulative development, which randomly contributes to the three blastocyst lineages.
- Recent studies show that early blastomeres in mouse and human embryos actually have distinct developmental fates and differences in protein levels, challenging the previous notion of randomness.
- Utilizing advanced proteomics, researchers found that 2-cell embryos contain alpha and beta blastomeres with different protein abundances linked to their developmental potential, with beta blastomeres more likely to produce higher amounts of epiblast cells.