[Inhibiting effect of the polyphenolic complex from Plantago major (plantastine) on the carcinogenic effect of endogenously synthesized nitrosodimethylamine].

Amidopyrine administered in combination with sodium nitrite in the long-term experiment produces the toxic damage of the liver and tumors in rats in connection with endogenic synthesis of carcinogenic nitrosodimethylamine. The inclusion into the animal diet of the polyphenolic complex from Plantago major--plantastine as an inhibitor of the carcinogen synthesis reduced the toxic damage of the liver that was indicated by normalization of biochemical parameters and also decreased the tumor yield from 87.5% to 33.

[Food inhibitors of the formation of carcinogenic nitroso compounds].

A study was made of the effect of plant preparations, pectin, plantastin, tiliaflan, cholosas and carbonic acid phytoextract from the fruit of the Umbelliferae family (CO2-EP) on the synthesis of carcinogenous nitrosodimethylamine from amidopyrine and sodium nitrite. Gas chromatography made in vitro and in short-term experiments on animals demonstrated plantastin to display an inhibitory action, which was less marked for tiliaflan, CO2-EP and cholosas. The system of experiments in question may be recommended for preliminary screening of the inhibitors of nitrosation with a purpose of using them for the prophylaxis of carcinogenesis induced by nitroso compounds.

[Biochemical characteristics of major fractions of rat liver cells in dimethylnitrosamine-induced carcinogenesis].

The report deals with a comparative study of the morphological and biochemical indexes in the fractions of parenchymal and non-parenchymal isolated cells of rat's liver, both intact and treated with a polytropic carcinogen-nitrosodimethylamine (NDMA)-for seven months. A higher susceptibility of parenchymal cells to NDMA was established.

[Effect of different kinds of Ocean paste on rat liver biochemical indices in sodium fluoride poisoning].

The paper is concerned with the effect of diets including three chemically different types of the "Ocean" paste on biochemical characteristics (glycolysis, the content of phosphofructokinase, dehydrogenase, glucoso-6- phosphate, demethylase, dimethylalaniline hydroxylase, ascorbic acid) of the liver of rats exposed to sodium fluoride overdosage. The test diets were compared with those containing conventional sources of protein (casein, beef). Acute exposure to sodium fluoride caused changes in the biochemical characteristics.