Efficient delivery of the immunodominant genes of African swine fever virus by adeno-associated virus serotype 2.

Background And Aim: Adeno-associated virus serotype 2 (AAV2) represents a promising basis for developing a virus-vector vaccine against African swine fever (ASF). This study aimed to create genetic constructs based on AAV2 to deliver the immunodominant genes of ASF virus (ASFV) and to evaluate their functionality . The efficiency and specificity of transgene expression, as well as their non-toxicity in cells of target animals, were evaluated.

Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection.

To obtain fiber materials with pronounced chemical-biological protection, metal (Zn or Ta) nanoparticles were jointly applied with polyelectrolyte complexes of enzymes and polypeptides being their stabilizers. Computer modeling revealed the preferences between certain polyelectrolyte partners for -acyl-homoserine lactone acylase and hexahistidine-tagged organophosphorus hydrolase (His-OPH) possessing the quorum quenching (QQ) behavior with bacterial cells. The combinations of metal nanoparticles and enzymes appeared to function better as compared to the combinations of the same QQ-enzymes with antibiotics (polymyxins), making it possible to decrease the applied quantities by orders of magnitude while giving the same effect.

Metal Nanoparticles for Improving Bactericide Functionality of Usual Fibers.

A wide variety of microbiological hazards stimulates a constant development of new protective materials against them. For that, the application of some nanomaterials seems to be very promising. Modification of usual fibers with different metal nanoparticles was successfully illustrated in the work.

Effect of concentrated light on morphology and vibrational properties of boron and tantalum mixtures.

Heating a mixture of boron (impurities: carbon ∼ BC, boric acid - HBO) and tantalum (Ta) powders in nitrogen flow in a xenon high-flux optical furnace was performed. As-received powder composed of h-BN, HBO, TaB, BH and a number of other phases including β-rhombohedral boron, apparently, heavily doped with Ta. FT-IR examination of any sample of the material reveals the complicated vibration spectrum containing, in particular, an absorption band near 2260 cm.

[Health-care provision to the rescue and other emergency operations in case of radiation accidents at facilities under FMBA of Russia service].

The article deals with the main tasks of health-care provision to the rescue and other emergency operations (ROEO) and organization of medical evacuation system FMBA of Russia in case of radiation accidents. The risk (threat) for workers engaged in ROEO, depending on the level of exposure of the radiation factor, is analyzed and recommendations for protective measures are considered. The authors showed the important role of the practical skills and knowledge of staff of institutions of FMBA of Russia and emergency response teams of radiation-hazardous facilities for address issues of healthcare provision to ROEO.