Publications by authors named "G P Farronato"
The oral and gastrointestinal mucosae represent the main targets of the toxic effect of chemo and/or radiotherapy administered during the conditioning regimen before hematopoietic stem cell transplant (HSCT). These harmful consequences and the immunological complications that may occur after the transplant (such as Graft versus Host Disease, GvHD) are responsible for the clinical symptoms associated with mucositis during the aplasia phase, like pain, nausea, vomiting, and diarrhea. These toxicities could play a critical role in the oral and gastrointestinal microbiomes during the post-transplant phase, and the degree of microbial dysbiosis and dysregulation among different bacterial species could also be crucial in intestinal mucosa homeostasis, altering the host's innate and adaptive immune responses and favoring abnormal immune responses responsible for the occurrence of GvHD.
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- - The global infertility crisis and rising infant mortality from preterm births have sparked interest in artificial placenta (AP) and artificial womb (AW) technologies, which replicate the conditions of a natural womb by providing nutrients and managing waste for developing fetuses.
- - This review highlights the history and potential applications of AP and AW technologies while examining the challenges and ethical issues surrounding their development and use.
- - Ongoing research is necessary to explore possible negative effects of these technologies and to address ethical concerns before they can be widely implemented.
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- The article provides an overview of human cloning, discussing its history, biological mechanisms, and societal impacts, with a focus on techniques like somatic cell nuclear transfer (SCNT).
- It highlights advancements in cloning technology, including successful animal cloning and potential future improvements like gene editing and embryo reprogramming.
- The ethical implications of human cloning are examined, particularly regarding human dignity, identity, and kinship, emphasizing the need for careful governance and consideration of safety and exploitation concerns.
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- * He significantly advanced the understanding of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) through his leadership in initiatives like the ME Biobank and EUROMENE, emphasizing patient education and treatment development.
- * In addition to his scientific contributions, Professor Pheby was also involved in humanitarian efforts, child protection advocacy, and served on the Independent Ethics Committee of MAGI, leaving behind a legacy of compassion and innovation in medical research.
Article Synopsis
- Animal experimentation is used to understand diseases and find treatments for both people and animals, with most tests done on rats, mice, and birds.
- Many people are against using animals for research because they feel animals can suffer and because it's unclear if results from animals always help humans.
- Ethical guidelines called the 'four Rs' (Reduction, Refinement, Replacement, Responsibility) help researchers consider animal welfare, but we still need more research to find alternatives that can completely replace animal testing.