Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli.

Phage therapy has recently been revitalized in the West with many successful applications against multi-drug-resistant bacterial infections. However, the lack of geographically diverse bacteriophage (phage) genomes has constrained our understanding of phage diversity and its genetics underpinning host specificity, lytic capability, and phage-bacteria co-evolution. This study aims to locally isolate virulent phages against uropathogenic Escherichia coli (E.

Index-based tools for livelihood security and resilience assessment (LiSeRA) in lower Mekong Basin.

This paper presents a framework and toolkit for assessment of multi-hazard livelihood security and resilience in the Lower Mekong Basin (LMB) communities. The LMB is a subsidiary region of the Mekong region in South East Asia, and is frequently exposed to hydrometeorological hazards and anthropogenic stressors that expose and directly affect the livelihoods of more than sixty-five million people living in the region. The main purpose of the study is to support decision-making and risk management planning through integration of the concepts of livelihood security and resilience into a holistic framework, and subsequently developing an index-based toolkit for conducting assessments.

Senior Citizens in Nepal: Policy Gaps and Recommendations.

Limited research has been conducted on the views of senior citizens in Nepal with regards to contemporary challenges and aging issues. To better understand their existing problems, it is important to talk to and survey senior citizens and reflect on their experiences and insights. The Senior Citizens Acts, 2063 in Nepal defines senior citizens as individuals who have reached the age of 60 years or above.

Exponentiated Odd Lomax Exponential distribution with application to COVID-19 death cases of Nepal.

This study suggested a new four-parameter Exponentiated Odd Lomax Exponential (EOLE) distribution by compounding an exponentiated odd function with Lomax distribution as a generator. The proposed model is unimodal and positively skewed whereas the hazard rate function is monotonically increasing and inverted bathtubs. Some important properties of the new distribution are derived such as quintile function and median; asymptotic properties and mode; moments; mean residual life, mean path time; mean deviation; order statistics; and Bonferroni & Lorenz curve.

Isolation and Characterization of Lytic Bacteriophage Against Multi-drug Resistant Pseudomonas aeruginosa.

Background: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen frequently causing healthcare-associated infections. The apocalyptic rise of antimicrobial resistance has rekindled interest in age-old phage therapy that uses phages (viruses that infect bacteria) to kill the targeted pathogenic bacteria. Because of its specificity, phages are often considered as potential personalized therapeutic candidate for treating bacterial infections.