Publications by authors named "G P Dalton"
Article Synopsis
- Autism Spectrum Disorder (ASD) is primarily seen in males and is marked by difficulties in communication and social behaviors, which this study examined using a mouse model.* -
- The research utilized various sequencing techniques to discover differences in gene expression and methylation patterns in the amygdala of two mouse strains, revealing potential links to sociability deficits.* -
- Results indicated that altered immune-related processes and oligodendrocyte/microglia differentiation were associated with ASD traits, highlighting the need for further research into these mechanisms and the effects of oxytocin.*
Article Synopsis
- Autism Spectrum Disorder (ASD) is linked to communication and social behavior challenges, with this study exploring the underlying brain mechanisms and sex differences in ASD using mouse models.
- Research involved measuring sociability in mice, analyzing gene expression changes, and identifying differentially methylated genes related to immune processes in the amygdala.
- Results showed significant differences in social behavior and brain activity between mouse strains, including impaired myelination linked to ASD, with potential therapeutic insights regarding oxytocin, but further studies are needed to clarify these cellular mechanisms.
Background: Out-of-hospital cardiac arrest (OHCA) is associated with very poor clinical outcomes. An optimal pathway of care is yet to be defined, but prognostication is likely to assist in the challenging decision-making required for treatment of this high-risk patient cohort. The MIRACLE score provides a simple method of neuro-prognostication but as yet it has not been externally validated.
View Article and Find Full Text PDFMetabolic syndrome (MS) is a risk factor for breast cancer (BC) that increases its aggressiveness and metastasis. The prevalence of MS is higher in triple-negative breast cancer (TNBC), which is the molecular subtype with the worst prognosis. The molecular mechanisms underlying this association have not been fully elucidated.
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