Production of the PET bone agent (18)F-fluoride ion, simultaneously with (18)F-FDG by a single run of the medical cyclotron with minimal radiation exposure- a novel technique.

Our aim was to establish an easy and convenient procedure for the preparation of fluorine-18-sodium fluoride ((18)F-NaF) for bone positron emission tomography (PET) during routine (18)F-FDG production using the Explora FDG4 radiochemistry module (EFRM) by single run of Cyclotron with negligible radiation exposure. We compared three techniques for (18)F-NaF production during routine PET radiochemistry at our setup. In one method we used synthesis module and in other two methods we did not.

Radiation exposure to nuclear medicine personnel handling positron emitters from Ge-68/Ga-68 generator.

Objective: To measure the radiation exposure to nuclear medicine personnel during synthesis and injection to the patients of Ga-68 1,4,7,10-tetraazacyclododecane-N,N',N″,N″'-tetraacetic acid (DOTA)-1-Nal(3)-octreotide (NOC)- (DOTA-NOC) using ring thermoluminescence dosimeters (TLDs).

Materials And Methods: Synthesis of Ga-68 DOTA-NOC was done on a semi-automated system. Finger doses were measured during synthesis and injection of Ga-68 DOTA-NOC.

Role of rhenium-188 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions refractory to conventional therapy.

Aim: To evaluate the treatment response of rhenium-188 (¹⁸⁸Re) tin colloid radiosynovectomy (¹⁸⁸Re-RSV) in patients with inflammatory knee joint conditions refractory to conventional treatment.

Materials And Methods: Sixty-one knee joints in 48 patients with chronic synovitis caused by various inflammatory knee joint diseases refractory to conventional therapy were included in this prospective study. All patients were assessed clinically for pain, tenderness, joint swelling, mobility, analgesic intake, and blood pool activity on bone scan.

Imaging of recurrent brain tumors with trivalent (99m)Tc-dimercaptosuccinic acid - initial results.

There is considerable chemical and structural similarity between the widely used oncophilic substance pentavalent dimercaptosuccinic acid labeled with (99m)Tc [(99m)Tc-DMSA(V)] and the renal imaging agent trivalent [(99m)Tc-DMSA(III)]. Other renal imaging agents like diethyltriamine penta acetic acid (DTPA) and glucoheptonate labeled with (99m)Tc have been used for imaging brain lesions, mainly for brain tumor imaging. The aim of this study was to evaluate technetium labeled (99m)Tc-DMSA(III) for brain tumor imaging.

Thallium-201 versus Tc99m-glucoheptonate SPECT for evaluation of recurrent brain tumours: a within-subject comparison with pathological correlation.

Background: Thallium-201 (Tl-201) is the most commonly used tracer for functional imaging of recurrent brain tumours. However, the physical properties of Tl-201 are not particularly suitable for this application, thus, a technetium-99 (Tc99m) labelled alternative with more favourable physical properties has been sought. The aim of this study was to compare the ability of Tl-201 and Tc99m-glucoheptonate single photon emission computed tomography (SPECT) to detect viable recurrent tumour and differentiate post-radiation gliosis.