Publications by authors named "G Ottini"
Article Synopsis
- Poorly differentiated sinonasal carcinomas (PDSNCs) are rare, aggressive tumors that include different types like squamous cell carcinoma and sinonasal undifferentiated carcinoma, with various epigenetic markers suggested for classification and prognosis.
- Recent studies have identified specific subtypes of sinonasal carcinomas linked to particular genetic mutations, indicating that these should be categorized as separate entities for better treatment strategies.
- A study of 53 PDSNC cases found a significant relationship between genetic defects and abnormal DNA methylation levels, which correlated with worse patient outcomes, highlighting the importance of genetic and epigenetic profiling in treatment planning.
Exploring the role of nasal cytology in chronic rhinosinusitis.
Acta Otorhinolaryngol Ital
October 2020
Objective: Characterising the eosinophilic profile represents the main step in chronic rhinosinusitis (CRS) endotyping. The aim of the study is to verify the correlation between different methods for tissue eosinophilia quantification.
Methods: 33 CRS patients undergoing endoscopic sinus surgery and 30 controls undergoing non-CRS surgeries were enrolled.
The aim of this study is to describe the clinicopathological characteristics of intranasal pleomorphic adenomas (PAs), as well as the role and outcomes of endoscopic endonasal resection. A retrospective review of the clinical data from patients with PA of the nasal cavity who were treated by the authors at three tertiary medical centers between June 1998 and December 2019. A total of five patients with PA were found.
View Article and Find Full Text PDFObjectives: Adenoid cystic carcinoma (ACC) is a locally aggressive salivary gland malignancy prone to perineural invasion and local recurrences. In the literature, few data exist to guide treatment when this tumor involves the paranasal sinuses and skull base. We report our experience in the management of sinonasal adenoid cystic carcinoma through an endoscopic endonasal approach.
View Article and Find Full Text PDFDifferent risk factors are suspected to be involved in malignant transformation of sinonasal papillomas and include HPV infection, tobacco smoking, occupational exposure, EGFR/KRAS mutations and DNA methylation alterations. In our study, 25 inverted sinonasal papillomas (ISPs), 5 oncocytic sinonasal papillomas (OSP) and 35 squamous cell carcinomas (SCCs) from 54 patients were genotyped for 10 genes involved in EGFR signalling. HPV-DNA detection was performed by in-situ hybridisation and LINE-1 methylation was quantitatively determined by bisulphite-pyrosequencing.
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