Publications by authors named "G Oszkinis"

The broad spectrum of clinical manifestations caused by peripheral arterial disease [PAD] and the morphologic heterogeneity of associated atherosclerotic lesions present a considerable management challenge. Endovascular interventions are recognized an effective treatment for PAD. Within this revascularization strategy the role of atherectomy debulking modalities continue to evolve.

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Background: Published reports demonstrate that the use of Castor stent-graft is a promising treatment of aortic pathologies with the need to land in zone 2. However, there is a lack of publications on the medium-term results of Castor in the European population. This research evaluates the mid-term results of the Castor stent-graft in several Polish centers for the treatment of aortic pathologies and enriches the current knowledge of Castor stent-grafts.

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Article Synopsis
  • Abdominal aortic aneurysm (AAA) has a significant genetic component, with a study identifying 141 genetic associations, including 97 that were previously unknown.
  • The research highlighted key biological pathways related to AAA, such as lipid metabolism, vascular development, and inflammation, indicating how these factors contribute to the disease's progression.
  • The study also suggests that lowering non-high-density lipoprotein cholesterol could be beneficial for AAA patients, advocating for the use of PCSK9 inhibitors based on evidence from a mouse model where PCSK9 loss prevented AAA development.
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The aim of the study was to examine the periodontal status of patients with atherosclerosis and abdominal aortic aneurysms. The occurrence of 5 periodontopathogens was evaluated in periodontal pockets and atheromatous plaques together with specimens from pathologically changed vascular walls of aortic aneurysms. The study comprised 39 patients who qualified for vascular surgeries.

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The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of this study was to investigate the expression and prognostic significance of VEGF and CXCR4, which are responsible for angiogenesis and progression in gastric cancer. Twenty-eight gastric cancer patients were analyzed.

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