Publications by authors named "G Ostapowicz"
Aim: To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal (GI) endoscopy services.
Methods: The literature was searched for publications reporting nurse endoscopy using several databases and specific search terms. Studies were screened against eligibility criteria and for relevance.
Background And Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-λ3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-λ3 genotype frequency among the different ethnic populations.
Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment.
Article Synopsis
- Frameshift mutations in the ALAS2 gene lead to increased enzyme activation, resulting in elevated levels of protoporphyrin in patients with X-linked dominant protoporphyria (XLDPP).
- In a study of four new XLDPP families, researchers discovered two novel mutations alongside a known one, suggesting a broader mutation spectrum and the role of mosaicism in the prevalence of the delAGTG mutation.
- The study proposes a large gain-of-function domain in the C-terminus of ALAS2, with experiments confirming a specific region that regulates enzymatic activity, which is proposed to be inhibited through its own C-terminus.
Objective: To determine hepatitis C (HCV) treatment effectiveness and predictors of response in the "real-world" Australian clinic setting.
Design, Setting And Participants: Patients with chronic HCV, who were HCV-treatment-naive at enrolment, and were then treated with standard therapy (pegylated interferon-α plus ribavirin), were recruited prospectively through a national network of 24 HCV clinics between April 2008 and December 2009. Patients were interviewed and a medical record review was conducted at enrolment and at routine follow-up clinic visits.
An association between non-alcoholic fatty liver disease and polycystic ovarian syndrome.
J Gastroenterol Hepatol
February 2009
Objectives: The aim of this study was to determine if there is an association between non-alcoholic fatty liver disease (NAFLD) and polycystic ovarian syndrome (PCOS). NAFLD and PCOS are both known to be associated with metabolic syndrome/insulin resistance.
Method: Fourteen consecutive female patients of reproductive age (20-45) either with liver biopsy proven NAFLD (50%) or abdominal ultrasound (US) consistent with steatosis together with elevated ALT levels (50%) were screened for PCOS using 2003 Rotterdam consensus meeting criteria.