Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Elderly Female with Cranial Polyneuropathy.

Unlabelled: The recrudescence of Varicella Zoster Virus in the head and neck region often manifests as Ramsay Hunt Syndrome, characterised by facial nerve palsy, vesicular rash in the distribution of facial nerve and neuralgia. Rarely it causes cranial polyneuropathy (CP). We present a case of herpes zoster with CP, highlighting the diagnostic challenges and management in a resource-limited setting.

Assessment of Quality-of-Life Measurement Instruments for Chronic Otitis Media: A Systematic Review Using the COnsensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) Checklist.

Unlabelled: The purpose of our study is to assess the psychometric measurement properties of various questionnaires for quality of life in adult patients with chronic otitis media (COM) using the preferred reporting items for systematic reviews and meta-analysis protocol and the COnsensus based Standard for the selection of health Measurement Instruments (COSMIN) checklist. A thorough electronic search was performed with a date limitation of 23rd September 2021 using the following five electronic databases: OVID, Embase, Cochrane Library, PubMed, and Scopus. Only full-text articles in the English language about the development or validation of a self-administered measurement instrument to assess QOL in COM patients (≥ 18 years) that assesses one or more of the measurement properties developed by the COSMIN guidelines were included in the study.

Assessment of acoustic characteristics of speech in patients with bilateral abductor vocal cord paralysis following trans oral carbon dioxide LASER posterior cordotomy.

Aims: The study aimed to assess voice quality in patients with bilateral abductor vocal cord paralysis (BAVCP) following transoral carbon dioxide (CO2) LASER posterior cordotomy with acoustic parameters.

Materials And Methods: Twenty-five participants were recruited over a three-year duration. Voice analysis was done twice, pre-operatively and three months post-operatively in decannulated patients, with the help of Praat software (Version 6.

The R337C mutation in the p53 oligomerization domain affects the regulatory domain and its ability to bind response elements: Evidence based on structural and biophysical studies.

The homotetrameric form of p53 is critical for performing essential functions like maintaining genomic stability and preventing uncontrolled cell proliferation. In part, these crucial functions are mediated by the p53 C-terminal region (CTR) containing the tetramerization/oligomerization domain (TD/OD) and regulatory domain (RD) responsible for the protein's oligomeric state and regulating the p53 function. Mutations in the tetramerization domain decrease the transactivation potential and alter the transactivation specificity of p53.